住院患者抗菌药物的使用实施干预的调查研究

Intervention in Antimicrobial Agent Use for Hospitalized Patients

目的通过综合干预促进住院患者抗菌药物的临床合理应用。方法抽取手术病历和非手术病历各100份,利用抗菌药物合理使用的国际指标进行抗菌药物使用情况的调查,采用行政管理和宣传教育等多手段进行干预,评价指标中医院整体情况数据通过管理部门和药库获得,处方行为和患者治疗情况通过系统抽样方法采集。结果接受抗菌药物治疗的住院患者使用抗菌药物的平均品种数从干预前的2.13种降到干预后的1.97种,住院患者接受抗菌药物治疗的平均费用从干预前的1765.23元降到干预后的1136.18元,经统计学处理差异有统计学意义(P<0.05),使用抗菌药物通用名的百分率从干预前的32.65%上升到干预后的73.21%(P<0.05),其他各项指标均有改善。结论本研究采用的合理用药干预措施具有可行性和有效性,对抗菌药物安全、有效、经济的使用起到了积极的促进作用。

OBJECTIVE To enhance the rational usage of antimicrobial agents in hospitalized patients by comprehensive interventional measures in clinics. METHODS The selected indictors recommended by WHO were applied to evaluate the use of antimicrobial agents in hospitalized patients. The hospital information was gained from hospital administration section. The prescription and treatment data were collected from the discharged patients＇ medical history. Intervention was involved in managerial and educational strategies. RESULTS After intervention, the average number of antirnicrobial agents prescribed per inpatient fell from 2. 13 to 1. 97. The average cost of antimicrobial agents prescribed per inpatient fell from 1765.23 yuan to 1136.18 yuan （P〈0.05）. The generic name of antimicrobial agents prescribed per inpatient increased from 32.65% to 73.21% （P〈0.05）. Some other indicators also were changed, which impied the benefit of the intervention. CONCLUSIONS The intervention methods used in this study are proved practicable and effective for rational drug use. They will contribute to the safe, effective and economic use of antimicrobial agents in China.