心血管病医院医院感染病原菌及耐药分析

Drug-resistance of Pathogens in Cardiovascular Hospital

目的 了解阜外心血管病医院医院感染主要病原菌及耐药性，为临床合理使用抗菌药物提供依据。方法对2006—2007年医院分离的病原菌采用法国生物梅里埃公司VITEK32全自动微生物鉴定分析仪进行鉴定和药敏试验，用WHONET5．4软件进行统计分析。结果分离的病原菌中，以革兰阴性杆菌为主，对头孢他啶、头孢吡肟、阿米仁星、头孢哌酮／舒巴坦、哌拉西林／他唑巴坦敏感率较高，可达50．9％～94．7％；除铜绿假单胞菌外，对亚胺培南和美罗培南敏感率高，敏感率为98．7％～100．0％；革兰阳性球菌中，粪肠球菌对青霉素，高水平庆大霉素敏感率较高，敏感率分别为84．5％和94．5％；屎肠球菌对其敏感率低，敏感率分别为4．5％和11．9％；葡萄球菌属中以耐甲氧西林凝固酶阴性葡萄球菌为主，其对常用抗菌药物敏感率低；未出现万古霉素和替考拉宁耐药的葡萄球菌属和肠球菌属。结论了解医院感染病原菌的分布及耐药性，对临床合理使用抗菌药物，预防与控制医院感染发挥有效作用。

OBJECTIVE To investigate the pathogens and their drug-resistance in Fuwai Cardiovascular Hospital and provide antibiotics use suggestion for clinical treatment. METHODS The pathogens were identified by VITED 32 and analyzed by WHONET 5. 4 RESULTS The pathogens mainly consisted of Gram-negative bacilli, which were highly sensitive to imipenem and meropenem except Pseudomonas aeruginosa ; E. faecalis was much more sensitive to penicillin and gentamicin than E. faecium. Most coagulase-negative Staphylococcus （CNS） were resistant to oxacillin and showed low susceptibility rates to most antibiotics. No Gram-positive cooci were found to be resistant to vancomycin and teicoplanin. CONCLUSIONS To investigate the pathogens and their drug resistance is very important to prevent and control nosocomical infections.