奥扎格雷氯化钠注射液治疗老年糖尿病下肢动脉病变的临床研究

Clinical study of the effect of ozagrel sodium and sodium chloride injection on lower limb angiopathies in aged diabetic patients.

目的观察奥扎格雷氯化钠注射液治疗老年糖尿病下肢动脉病变的效果。方法80例老年糖尿病患者随机分为2组，均给予常规治疗。治疗组给予奥扎格雷氯化钠注射液100ml，每日2次；对照组给予丹参注射液800mg加入生理盐水250ml中，每日静脉滴注1次；均3周为1疗程。观察治疗前后血糖、TC、TG、SCr、ALT和足背动脉血流量指标的变化。结果治疗组总有效率为92．5％，对照组为85．0％，2组总有效率比较差异有统计学意义（x^2=3．99，P〈0．05）；足背动脉血流速度治疗组、对照组分别为（0．65±0．16）、（0．61±0．10）（v·s）／m，2组比较差异有统计学意义（t=2．16，P〈0．05）；影肱血压指数治疗组与对照组分别为（0．99±0．29）、（0．92±0．13），2组比较差异有统计学意义（t=2．45，P〈0．05）。结论奥扎格雷氯化钠注射液有助于老年糖尿病下肢动脉病变的治疗。

Objective To investigate the efficacy of ozagrel sodium and sodium chloride injection on lower limb angiopathies in aged diabetic patients. Methods Eighty aged diabetic patients with lower limber angiopathies were divided into treatment group （n = 40, regular theraph ＋ ozagrel sodium and sodium chloride injection） and control group （ n = 40, regular theraph ＋ salvia mihiorrhiza injection）. The course of treatment was 3 weeks. Before and after treatment, blood sugar, total cholesterol, triglyceride, serum creatinine, alanine aminotransferase and blood current velocity degree of lower extremity were determined. Results The efficacy rates reached 92.5% and 85.0% in the treatment and control groups respectively, with obvious significance （ x^2 = 3.99, P 〈 0.05 ）, blood current velocity degree of lower extremity in the treatment and control groups were also significant diffrent [ （0.65 ± 0.16）（ v. s）/m and （0.61 ±0.10） （v. s）/m] （t =2.16,P 〈0.05）. The ankle/humerus ratio is statatisticaly different （0.99 ± 0.29,0.92 ±0.13, t = 2.45, P 〈 0.05 ）, Conclusion Ozagrel sodium and sodium chloride injection plays a beneficial role in the treatment of lower limb angiopathies in aged diabetic patients.