摘要
合成了１８种２，２－二取代－５－亚苄（糠）基环戊酮类化合物，结构均通过核磁、红外、元素分析等予以确证．初步药理实验结果显示：该类化合物对鼻咽癌、结肠癌、卵巢癌和肺腺癌等癌细胞具有一定的抑制作用；某些化合物还有杀菌作用．
Eighteen substituted cyclopentanones containing cyclopentenyl were synthesized. Their chemical structures were confirmed by elemental analysis, IR and 1H NMR measurements. The anticancer activities of the compounds have been examined. Compounds 2l, 2e and 2r were found to be active against KB, HCT, A2780, and A549 tumors in vitro. Compounds 2b and 2d showed activity only against HCT tumor. Compound 2e showed some fungistatic activity against plant pathogens in vitro.
出处
《应用化学》
CAS
CSCD
北大核心
1998年第2期32-35,共4页
Chinese Journal of Applied Chemistry
基金
中国博士后科学基金
关键词
抗癌药
环戊酮
杀菌活性
亚苄基
衍生物
亚糠基
benzal(fural) cyclopentanones,synthesis,anticancer,antifungal activity
