尿液癌细胞阳性患者前列腺特异性抗原分析

The analysis of serum prostate-specific antigen(PAS) in patients with cancer cell in urine

目的探讨尿液脱落细胞学检查联合血清前列腺特异性抗原(PSA)鉴别尿液中癌细胞来源。方法应用全自动AXSYM发光免疫分析仪对32例尿癌细胞阳性者进行总前列腺特异性抗原(TPSA)、游离前列腺特异性抗原(FPSA)和FPSA/TPSA比值测定,分为前列腺癌(PCa)组、膀胱癌伴前列腺增生(BPH)组、膀胱癌不伴BPH组,分别与正常体检对照组对照。结果PCa组TPSA、FPSA与正常人及膀胱癌组比较差异有显著意义(P<0.05),FPSA/TPSA与正常人及膀胱癌不伴BPH组比较差异有显著意义(P<0.05)。结论PCa组TPSA、FPSA明显高于正常对照组及膀胱癌组,FP-SA/TPSA明显低于正常对照组及膀胱癌伴BPH组,尿液脱落细胞学检查联合PSA测定可作泌尿系肿瘤来源于前列腺还是非前列腺的鉴别。

Objective To study the urine cancer cell recourse discrimination by urine exfoliate cytology in combination with serum PSA measurement. Methods Measured the total--PSA（TPSA）, free--PSA（FPSA）,and FPSA/TPSA ration in 32 eases patients with cancer cell in urine by automatic AX-SYM luminescence immunoassay system, divided into 3 groups; prostate cancer （pCa） group, bladder cancer accompany with benign prostate hyperplasia （BPH） group, and bladder cancer without BPH group,and compared the results in these 3 groups with those in healthy control. Results TPSA,FPSA in pCa group had marked differences with healthy control and bladder cancer group, （P〈0.05）. FPSA/TPSA in pCa group had marked differences with healthy control and bladder cancer without BPH, （P〈0.05）. Conclusions TPSA,FPSA in pCa group were obviously higher than healthy control and bladder cancer group, FPSA/TPSA in pCa group were obviously lower than healthy control and bladder cancer accompany with BPH. Urine exfoliative cytology in combination with measurement of serum PSA can help to know the resource of urinary tract tissue tumor,wlaether from prostate gland or not.