合成水苏碱对功血模型大鼠子宫血管舒缩因子的影响

Effects of Synthesis Stachydrine on ET and NO of Dysfunctional Uterine Bleeding

目的:观察经化学方法低成本合成的水苏碱在治疗功能性子宫出血时对子宫血管舒缩因子一氧化氮和内皮素的影响。方法:采用米非司酮加米索前列醇致早孕大鼠流产复制功能性子宫出血模型,测定一氧化氮和内皮素含量。结果:水苏碱能够明显降低功能性子宫出血模降低子宫匀浆一氧化氮含量,增加子宫平滑肌血管内皮素含量(P<0.05或P<0.01)。结论:实验结果初步阐明了收缩子宫血管是水苏碱治疗功能失调性子宫出血的的途径之一。

Objective：to observe the effect of Synthesis Stachydrine on endothelin and nitric oxide（NO） of dysfunctional uterine bleeding. Methods：imitate the model rats according to pharmacy experimental method,and we measured the content of nitric oxide and endothelin. Results ： Synthesis Stachydrine can reducing NO, increase the level of ET. Conclusions ： Synthesis Stachydrine can cure dysfunc- tional uterine bleeding effctively.