对叶豆蒽醌类化学成分的研究

A Study of Anthraquinones Constituents in Cassia alata L.

目的:分离鉴定对叶豆(Cassia alata L.)中的化学成分,为其药效物质研究奠定基础。方法:采用溶剂萃取、正相硅胶色谱、凝胶色谱等方法进行分离;应用1D-NMR、2D-NMR、IR、UV、MS等谱学方法进行结构鉴定。结果:分离得到11个化合物:大黄酸、芦荟大黄素、大黄素、芦荟大黄素-8-O-β-D-葡萄糖苷、芦荟大黄素-3-(羟甲基)-O-β-葡萄糖苷、-生育酚、羽扇豆-20(29)-烯-3-酮、β-谷甾醇、2-乙基-3-甲基-马来酸酐、邻二甲氧基对羟基-E-肉桂酸、2,3-二乙酰基丁四醇分别鉴定。结论:除前三个化合物1、2和3外,其余8个化合物均是首次从对叶豆中分离得到。

This is a study to isolate and identify the chemical constituents in Cassia alata L. In the study, compounds were purified by column chromatography with silica gel and Sephadex LH-20, and elucidated using spectroscopic methods, including 1D and 2D NMR, IR, and MS techniques. Eleven compounds were isolated from Cassia alata L.. They were identified as Rhein （1）, Aloe-emodin （2）, emodin （3）, Aloe-emodin-8-O- -D-glucoside （4）, Aloe-emodin-3- hydrox- ymethyl- -D-glucopyranoside （5）, -Tocopherol （6）, Lup-20（29）-en-3-one （7）, β-sitosterol （8）, 2-ethyl-3-methylmaleic anhydride （9）, m-dimethoxy-p-hydroxy-E- cinnamic acid （10）, and 2,3-diacetylbutanetetrol （11）. Of them, compounds 4-11 were isolated from Cassia alata L. for the first time.