血浆内皮素测定和急性脑血管病康复分期关系的研究

Relationship between serum endothelin and convalcent stages in patients with acute CVD

目的：检测急性脑血管病患者血浆内皮素（ＥＴ）的浓度，探讨ＥＴ在疾病发展中的动态变化。方法：采用放射免疫法测定７８例急性脑血管病患者在不同康复分期的血浆ＥＴ浓度。结果：发现急性脑血管病患者的血浆ＥＴ水平于病程第３天（相当于康复早期）最高，第７天（相当于软瘫期）次之，第１４天（相当于软瘫期与痉挛期的过渡期）明显降低，但仍高于正常对照组，第３０天（相当于痉挛期）降至正常范围。

Objective:To explore the dynamical change of serum endothelin in the patients with acute cerebrovascular disease(ACVD).Method:To detect the serum endothelin by radioimmunology in different convalecent stages in 78 patients with ACVD.Result:The serum endothelin level in patients with ACVD increased most in the third day from the onset(equal the early convalecent stage),increased secondly in the seventh day(equal the soft palsy stage) decreased significantly but was higher than the normal in the fourtith day, and decreased to the normal in the thirtith day.Conclusion:The serum endothelin would be a helpful potential test to predict the different convalecent stage and to reflect the treatment in patients with ACVD. Author′s address\ Dept. of Neurology,Union Hospital of Fujian Medical University,Fuzhou,350001