草酸铂联合5-氟脲嘧啶和亚叶酸钙双周疗法治疗晚期大肠癌的临床观察

The clinical observation of semimonthly oxalipclation combined with 5-fu and leucovorin in treatment of advanced colorectal cancer

目的评价草酸铂联合5-氟脲嘧啶和亚叶酸钙双周疗法治疗晚期大肠癌的疗效及毒副反应。方法40例晚期大肠癌患者采用双周疗法：草酸铂100mg／m^2，静脉滴注2小时，第1天；亚叶酸钙200mg／m^2，静脉滴注2小时，第1天；5-氟脲嘧啶400mg／m^2于亚叶酸钙滴完后静脉推注，第1天；再用5-氟脲嘧啶2500mg／m^2注入化疗泵，持续灌注48小时。以上方案每2周重复1次，每2次为1个疗程。所有患者进行2-6个疗程治疗。结果40例患者中完全缓解（CR）4例，部分缓解（PR）15例，稳定（SD）16例，进展（PD）5例，总有效率为47.5％。主要毒副反应为外周神经感觉异常，恶心、呕吐和骨髓抑制等。结论草酸铂联合5-氟脲嘧啶和亚叶酸钙双周疗法治疗晚期大肠癌有较好的近期疗效，毒副反应能为患者耐受，值得临床推广应用。

Objective To evalute the efficacy and the oxicity reaction of semi-monthly oxaiipclation combined with 5-Fu and leucovorin in treatment of advanced colorectal cancer. Methods Forty patients with advanced colorectal cancer received semimonthly combined chemotherapy of L-OHP（100mg/m^2, iv. gtt for 2h, d1） in fusion followed by 2-hour in fusion of CF（200mg/m^2, iv. gtt, d1） then intravenous bolus of 5-Fu 400mg/m^2, then 48-hour infusion of 5-Fu^2 500mg/m^2 using an ambulatory pump. The treatment schedule was recycled every 14 days. One cycle consisted of twice chemotherapy regimens. The curative effect was evaluated two weeks later,and the response for effective patients were confirmed four weeks later. Results The total response rate was 47.5% in which CR 4 cases, PR 15cases, SD 16cases and PD 5cases of forty patients. The major toxic effects were neuro-sensory toxicity, mucositis, nausea and vomiting, bone marrow suppression etc. Conelusions Semimonthly L-OHP combined with 5-Fu and leucovorin regimen is effective in treatment of advanced colorectal cancer, and its toxicity reaction is tolerable.