孕妇下生殖道解脲脲原体感染与妊娠结局关系的探讨

A study on the relationship between the ureaplasma urealyticum infection in lower genital tract and the pregnant outcome.

应用聚合酶链反应（ＰＣＲ）技术，对２１６例妊娠１２～３７周孕妇的宫颈阴道分泌物和其中１０９例孕妇分娩时的羊水进行解脲脲原体（ＵＵ）ＤＮＡ检测，同时临床观察２１６例孕妇的妊娠结局。结果：宫颈阴道分泌物ＵＵＤＮＡ阳性率为４３０６％，宫颈阴道ＵＵＤＮＡ阳性组对应的羊水ＵＵ检出率明显高于阴性组（Ｐ＜０００５），两组平均孕周、平均出生体重、平均Ａｐｇａｒ评分（１分钟）以及胎儿窘迫、早产、剖宫产、低出生体重儿、低Ａｐｇａｒ评分和新生儿畸形的发生率无显著性差异（Ｐ＞００５），阳性组胎膜早破的发生率显著高于阴性组（Ｐ＜０００５）。提示：孕妇下生殖道ＵＵ感染与羊水ＵＵ感染和胎膜早破有关，而与胎儿窘迫、早产、剖宫产、低出生体重儿、新生儿窒息和新生儿畸形的发生无明显关系。

bjective:To explore the relationship between the maternal ureaplasma urealyticum(U U) infection in lower genital tract and the pregnancy outcome.Design:216 pregnant women between 12～37 weeks' gestation from our unit were investigated in the prospective clinical study.Using polymerase chain reaction(PCR),U U DNA was detected in the vaginal and cervical secretion from 216 cases and also in the amniotic fluid from 109 cases out of 216 cases.Pregnancy outcomes were observed clinically.Results:The positive rates of U U DNA by PCR in vaginal and cervical secretion were 43.06%.Pregnant women with positive U U DNA had higher positive rates of U U DNA in the amniotic fluid than those with negative U U DNA(P<0.005).There were no significant differences between the two groups in mean gestational weeks,mean birth weight,mean Apgar score and the incidence of fetal distress,preterm birth,cesarean,low birth weight,low Apgar score and congenital malformation(P>0.05).The incidence of premature rupture of membranes was higher in pregnant women with positive U U DNA than those with negative U U DNA (P<0.005).Conclusion:Maternal U U infection in lower genital tract was associated with amniotic fluid U U infection and premature rupture of membranes,but not significantly associated with fetal distress,preterm birth,cesarean,low birth weight,neonatal asphyxia and congenital malformation.