米非司酮配伍与不配伍甲基睾丸素治疗子宫肌瘤的临床研究

A clinical trial of mifepristone with of without methyltestosterone in the treatment of uterine leiomyoma.

目的：评价米非司酮配伍与不配伍甲基睾丸素治疗子宫肌瘤的临床效果。方法：有症状的子宫肌瘤患者６０例，随机分为两组，每组３０例。Ａ组：口服米非司酮及甲基睾丸素。米非司酮２５ｍｇ，甲基睾丸素５ｍｇ，每日１次，连服９０天；Ｂ组：口服米非司酮及安慰剂，服药方法同Ａ组。结果：两组治疗后均使患者发生闭经。Ａ组治疗后经量减少４９３２％，瘤体缩小５２２０％；Ｂ组治疗后经量减少３９８０％，瘤体缩小４４１０％。结论：抗雌孕激素的联合治疗是保守性治疗子宫肌瘤较为理想的方法。

Objective:To evaluate the response of uterine leiomyoma to mifepristone with or without methyltestosterone.Methods:60 cases of leiomyoma with symptoms were classified into two groups.Group A:30 patients were treated with 25mg of mifepristone and 5mg of methyltestosterone daily for 90 days.Group B:the other 30 patients were treated by mifepristone and consolation.Size of leiomyoma was measured by BUtrasonography.The changes of menstrual bleeding and duration were recorded.Blood samples for hemoglobin and hematocrit were checked before and after treatment.Result:Amenorrhoea was induced in all 60 patients,Menstrual flow were decreased (Group A:49.32%,Group B 39.8%)Anemia was cured and the size of leiomyoma decreased (Group A 52.5%,Group B 44.10%).Conclusion:The combined mifepristone with methyltestosterone is considered to be and ideal plan to treat uterine leiomyoma. \ \