甲状旁腺肿瘤中细胞周期素D1的表达及其临床意义

Expression of cyclin D1 in parathyroid tumors and its clinical significance

目的:探讨细胞周期素D1在甲状旁腺组织中的表达及其临床意义。方法:应用免疫组织化学法对3例甲状旁腺腺癌、8例甲状旁腺腺瘤、13例甲状旁腺增生、1例甲状旁腺囊肿以及10例正常甲状旁腺组织中细胞周期素D1的表达进行了检测。结果:甲状旁腺腺瘤组和腺癌组的细胞周期素D1过度表达比例高于正常甲状旁腺组(P<0.05);而甲状旁腺增生组与甲状旁腺腺癌组、腺瘤组和正常甲状旁腺组比较,差异无统计学意义(P>0.05)。结论:细胞周期素D1的过度表达在甲状旁腺腺瘤和腺癌的发生中起重要作用。

Objective： To investigate the expression of cyclin D1 in parathyroid tissues and its clinical significance. Methods： Immunohistochemical method was used to detect the expression of cyclin D1 in 3 parathyroid carcinoma tissues, 8 parathyroid adenoma tissues, and 13 proliferative parathyroid tissues, 1 parathyroid cyst, and l0 normal parathyroid tissues. Results： The overexpression ratio of cyclin D1 was significantly higher in parathyroid adenoma group and parathyroid carcinoma group than that in normal parathyroid group （P 〈 0.05 ）. There was no significant difference between parathyroid proliferation group and parathyroid carcinoma group, or parathyroid adenoma group, or normal parathyroid group （P 〉 0.05 ）. Conclusion： The overexpression of cyclin D1 played an important role in parathyroid adenoma and parathyroid carcinoma. Cyclin D1 might contribute to the etiology of parathyroid adenoma and carcinoma.