摘要
视网膜母细胞瘤(retinoblastoma,RB)是儿童最常见的眼内恶性肿瘤,预后较差,严重影响患儿视力甚至危及生命。临床表现主要为白瞳症,发病机制普遍认为是Rb基因的二次突变。治疗RB需按个体化的原则,并结合其病理分期。国内外就该病的治疗,包括眼球摘除术、放射疗法、化学疗法、药物疗法、激光光凝疗法、光动力疗法、温热疗法、冷冻疗法、基因疗法等已取得了一定的进展,本文现综述如下。
Retinoblastoma is the most common intraocular cancer of childhood, with bad prognosis. It may gravely affect children＇s vision, even jeopardizing to life. Leucocoria is the main clinical feature. The pathogenesy is generally recognized as twice mutation of retinoblastoma gene. Treatment of retinoblastoma must be individualized, and combined to its patho staging. We reviewed the new progression in the treatment of retinoblastoma, incluing enucleation, radiation therapy, chemotherapy, drug thera- py, photocoagulation, photodynamic therapy, thermotherapy, cryotherapy, and gene therapy etc.
出处
《国际眼科杂志》
CAS
2009年第1期139-141,共3页
International Eye Science
