先天性心脏病患儿认知功能损伤的胎生起源

Fetal Origins of Cognitive Disorder in Children with Congenital Heart Disease

随着外科手术技术的提高及精心的护理,先天性心脏病(CHD)患儿病死率显著降低,但随之而来的中枢神经系统后遗症日益成为关注的焦点。患儿生存时间的延长加深了对神经系统后遗症特别是认知功能障碍原因的探索,心脏矫正手术并不能纠正患儿的认知功能损伤,越来越多的研究推论CHD患儿认知功能障碍是宫内发育损伤的结果。

Advanced in medical and surgical management have led to reduce mortality in children with congenital heart disease （CHD）. However, more recent and ongoing research had been focused on neurodevelopmental outcome. With the improved survival in children follo- wing surgery for cardiac malformations, increased emphasis had being placed on neurological sequelae, especially on cognitive function. Cardiac surgery couldn＇t correct cognitive disorder,more and more findings suggested that the cognitive disorder of CHD might be the result of utero injury.