血清胱抑素C在检测糖尿病肾病中的价值

目的探讨血清胱抑素C(CysC)在糖尿病肾病中的应用价值。方法采用颗粒增强免疫比浊法检测80例健康人和100例糖尿病肾病患者的血清CysC浓度,同时检测血清尿素(Urea)和肌酐(Cr)浓度并与之比较。结果糖尿病性肾病患者组血清CysC、Urea和Cr结果分别为(1.98±0.99)mg/L、(10.54±2.58)mmol/L和(150.6±11.6)μmol/L,健康对照组血清CysC、Urea和Cr结果分别为(0.99±0.18)mg/L、(4.71±0.99)mmol/L和(88±8.7)μmol/L。糖尿病性肾病患者组血清CysC、Urea、Cr结果均明显高于健康对照组,经t检验,有显著性差异(P<0.01)。糖尿病肾病组中血清CysC、Urea和Cr阳性率分别为95%、66%和75%。血清CysC阳性率与血清Urea、Cr比较差异有显著性(P<0.01)。结论血清CysC在糖尿病肾病检测中有一定应用价值。

Objective To investigate the application value of serum cyctatinC （CysC） in patiens with diabetic nephropathy. Methods The value of serum CysC was measured by partide-enhanced immunonepe lometry in 100 patients with diabetic nephropathy and 80 health controls, and was compared with that of serum Urea and creatinine （Cr） . Results The results of the serum CysC , Urea and Cr were （ 1.98 ± 0. 99） rag/L, （ 10. 54 ± 2. 58） mmoL/L and （ 150. 6 ± 11.6） μmol/L in patiens group with diabetic nephropathy, the results of the serum CysC, Urea and Cr were （0. 99 ± 0. 18） mg/L. （4. 71 ± 0. 99） mmol/L and （88 ±8.7） μ mmol/L in a healthy control group. The serum CysC, Urea and Cr levels in patients with diabetic nephropathy were obviously higher than those in health controls, the difference among them was significant （ P 〈 0. 01 ） . The positive rate of CysC, Urea and Cr for diabetic nephropathy was 95% , 66% and 75% respectively. The positive rate of CysC was significantly higher than of Urea and Cr （ P 〈 0. 01 ） . Conclusion The CysC has a certain application value in dialectic nephropathy.