亚砷酸治疗急性早幼粒细胞白血病全血砷浓度及影响因素探讨

Blood arsenic concentration and influencing factors in treatment of acute promyelocytic leukaemia with arsenic trioxide

目的研究静滴亚砷酸治疗急性早幼粒细胞白血病（APL）全血砷浓度与红细胞数（RBC）、血红蛋白（HGB）、血细胞比容及白细胞数的关系，探讨这些因素对药效可能产生的影响。方法应用原子荧光法测定13例APL患者应用亚砷酸治疗后24h、第一周末全血砷浓度，观察RBC、HGB、HCT及WBC对血砷浓度的影响，分析其相关关系。结果13例白血病患者全血砷浓度与HGB、HCT存在显著相关关系，而与WBC数无相关性。结论血砷浓度受红细胞计数、血红蛋白浓度、血细胞比容的影响；白细胞数与血砷浓度无相关性。

Objective To study the relationship between blood arsenic trioxide （ATO） concentration and RBC count, hemoglobin,hematokrit,and WBC count;and to explore the possible influence of these factors on pharmacodynamics. Methods The whole blood ATO concentrations in 13 patients with acute promyelocytic leukemia were detected by atom - fluorometry spectra analysis. The effects of the patients＇ RBC, HGB, HCT on their whole blood ATO concentration were observed. Results The HGB and HCT had influ- ence on the blood ATO concentrations （ r 〉 0. 5, P 〈 0.05 ）. The WBC count and ATO concentration were negatively interrelated （ r 〈0.5）. Conclusions The RBC count, HGB and HCT have effects on the whole blood ATO concentration. The WBC has no influence on the blood ATO.