摘要
目的研究肝硬变门静脉高压症患者肝组织组胺Ｈ１和Ｈ２受体的变化。方法光学放射自显影术。结果Ｈ２受体密度在肝硬变患者肝细胞１６８４±２２６显著低于对照组５１１９±３７６（Ｐ＜００１）；肝静脉２３８８±４０７显著低于对照组３１３０±５２４（Ｐ＜００１）；肝动脉５５６±７１显著低于对照组１７５４±２６１（Ｐ＜００１）；门静脉５２０±５４显著低于对照组１６６４±１７７（Ｐ＜００１）；肝硬变患者Ｈ１受体密度在肝细胞、肝静脉、肝动脉和门静脉与对照组相比差异均无显著性意义（Ｐ＞００５）。
Objective To study histamine 1 and histamine 2 receptors in hepatic tissues of cirrhotic patients with portal hypertension. Method Light autoradiography was used. Result The density of histamine 2 (H 2) receptors (cirrhotic patients/ controls) in hepatocytes was 168 4±22 6/511 9±37 6( P <0.01), in hepatic vein 238 8±40 7/313 0±52 4 ( P <0 01),in hepatic artery 55 6±7 1/175 4±26 1( P <0 01), and in portal vein 52 0±5 4/166 4±17 7( P <0 01).The density of histamine 1 receptors in hepatocytes, hepatic vein, hepatic artery and portal vein was not statistically changed between cirrhotic patients and controls ( P >0 05). Conclusion The density of H 2 receptors in hepatic tissues of cirrhotic patients decreased significantly.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1998年第6期348-349,共2页
Chinese Journal of Surgery
基金
国家自然科学基金
