早孕妇女血清及绒毛组织中表皮生长因子的含量及米非司酮对其的影响

Effect of Mifepristone on the Concentration of Epidermal Growth Factor in Serum and Villi of Early Pregnant Women

目的探讨表皮生长因子（ＥＧＦ）对早期胚胎发育的影响和米非司酮对胚胎生长及ＥＧＦ的作用。方法采用放射免疫法测定６６例不同孕龄的早孕妇女（研究组）血清及绒毛组织中ＥＧＦ、血雌二醇（Ｅ２）和孕酮（Ｐ）及２０例正常育龄妇女（对照组）血清ＥＧＦ水平，并观察药物流产时米非司酮对绒毛组织中ＥＧＦ含量的影响。结果早孕妇女血清ＥＧＦ水平明显高于非孕妇女（Ｐ＜０．０１）；随孕龄的增长，血清ＥＧＦ、Ｅ２、Ｐ含量明显升高（Ｐ＜０．０５）。用米非司酮后，孕囊的增长幅度减小，血清中ＥＧＦ和Ｐ含量均有轻度下降；药物流产的绒毛中，ＥＧＦ含量明显低于人工流产者（Ｐ＜０．０５）。结论ＥＧＦ对胚胎发育具有重要作用。

Objective To investigate the change of epidermal growth factor (EGF) concentration in serum and villi of early pregnant women and its possible effects by mifepristone. Methods Twenty normal women as control and sixty six early pregnant women were enrolled for study. Serum EGF, estradiol (E 2) and progesterone (P) concentrations were measured with radioimmunoassay. EGF concentration in villi by surgical aspriation and mifepristone induced abortion were compared. Results Serum EGF concentration in early pregnant women was significantly higher than that in non pregnanct women ( P <0.01). The serum EGF, E 2 and P concentrations increased as pregnancy advanced ( P <0.05). The growth rate of gestational sac declined and serum EGF and P concentrations decreased slightly after administration of mifepristone. Villi EGF content in mifepristone group was significantly lower than that in surgical group ( P <0.05). Conclusion EGF may be involved in regulating embryo development. Mifepristone may interfere embryonic development via inhibiting EGF level.