获得性免疫缺陷综合征神经系统损害15例分析

Neurological involvement of 15 patients of acquired immunodeficiency syndrome

目的了解获得性免疫缺陷综合征（艾滋病）患者神经系统受累的临床特点。方法回顾性分析2002年2月至2008年2月于我院住院的，伴有神经系统受累的艾滋病患者15例，其中8例因神经系统症状而首诊于神经科。结果15例患者中人类免疫缺陷病毒（HIV）脑病者4例，其中1例表现为舞蹈症，1例HIV脑病合并HIV相关肌病；进行性多灶性白质脑病1例；进行性多灶性白质脑病合并弓形体脑病1例；HIV相关肌病1例；多脑神经损伤合并脊髓病1例；周围神经病1例；药物相关的神经肌肉病1例；脑膜脑炎4例；脑脓肿1例。结论艾滋病累及神经系统的部位及表现形式多样，在临床工作中应提高警惕，注意筛查。

Objective To explore the clinical features of nervous system involvement of acquired immunodeficiency syndrome （AIDS）. Methods A retrospective clinical analysis of 15 admitted AIDS patients with neurological involvement in our hospital from February 2002 to February 2008. Eight of them visited department of neurology for the first time. Results There were 4 cases of human immunodeficiency virus （HIV） encephalopathy, 1 of them appearanced as general chorea, 1 HIV-associated encephalopathy accompanied with myopathy ; 1 progressive multifocal leukoencephalopathy （PML） ; 1 PML accompanied with toxoplasmosis; 1 HIV-associated myopathy; l muhicranial nerve injury companied with myelopathy; 1 peripheral neuropathy;1 drug-associated neuromuscular disease; 4 meningoencephalitis and 1 brain abscess cases. Conclusion The manifestations and AIDS neurological involvement are varied. A close attention should be paid to screening.