胸膜肺炎放线杆菌RTX毒素与宿主的相互作用

Interaction between Actinobacillus pleuropneumoniae RTX toxin and host-A review

胸膜肺炎放线杆菌引起猪传染性胸膜肺炎,给养猪业造成严重的经济损失。RTX毒素是胸膜肺炎放线杆菌主要的毒力因子,在该病原的感染与免疫中发挥"双刃剑"的作用。本文综述了近十多年来国内外在胸膜肺炎放线杆菌RTX毒素的研究进展,提出了毒素与宿主互作研究的必要性和技术可行性,认为毒素与宿主相互作用研究将诠释此病原的分子致病机理。

Actinobacillus pleuropneumoniae （App） is the etiological agent of porcine pleuropneumonia which causes huge economic losses to the pig industry. RTX （repeat in the structural toxin, RTX） is the main virulence-associated factor of the pathogen and, plays a dual role on the pathogen＇s infection and immunity. Recently research progress is updated in this paper and the necessity and techniques to initiate the pathogen-host interaction study is also raised and discussed. It is believed that the research on the interaction between host and App RTX may further elucidate the pathogen＇s molecular pathogenesis.