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胃镜下可疑恶性溃疡MG7-Ag表达与临床随访二次活检病理结果的对照研究 被引量:2

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摘要 为了探讨胃镜下可疑恶性溃疡组织MG7-Ag表达对其临床随访、二次活检的辅助指导价值,对58例经首次胃镜检查可疑恶性溃疡、活检、病理未能确诊者的病理标本进行MG7-Ag的ABC免疫组化染色,同时进行1~72周(平均7周)临床随访。所有病人均再次胃镜复查,组织活检,病理检查。结果表明,MG7-Ag阳性表达30例中有19例二次活检病理检查确诊为胃癌(63.3%),阴性组28例中有5例确诊为胃癌(17.9%),两组胃癌检出率差异有非常显著意义(P<0.01)。结论:MG7-Ag阳性表达的胃镜下可疑恶性溃疡与胃癌关系密切,对这部分病人进行密切随访,有助于胃癌的早期发现。
出处 《沈阳部队医药》 2009年第1期23-24,共2页
基金 辽宁省自然科学基金项目 编号20052070
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  • 1吴文尧,张友安,王敏,马黔,宋玲,胡敏麟,郑洪喜.胃脘痛患者胃镜诊断与中医辨证分型关系探讨[J].中国中西医结合脾胃杂志,1996,4(2):72-75. 被引量:7
  • 2樊代明 张学庸 等.抗抵分化胃癌细胞系MKN-46-9单克隆抗体的制备及免疫组化鉴定[J].解放军医学杂志,1993,13(1):12-12.
  • 31.胃カメラによろ经遇觏察と胃癌.胃癌研究会编.日本の胃癌.东京:金原出版株式会社,1996.255-256.
  • 4Oh H,Mammucari C,Nenci A,et al.Negative regulation of cell growth and differentiation by TSG101 through association with p21Cip1/WAF1[].Proceedings of the National Academy of Sciences of the United States of America.2002
  • 5Ruland J,Sirard C,Eia A,et al.p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking TSG101[].Proceedings of the National Academy of Sciences of the United States of America.2001
  • 6Zhao Y,You H,Liu F,et al.Differentially expressed gene profiles between multidrug resistant gastric adenocarcinoma cells and their parental cells[].Cancer Letters.2002
  • 7Shi Y,Han Y,Wang X,et al.MGr1-Ag is associated with multidrug-resistant phenotype of gastric cancer cells[].Gastric Cancer.2002
  • 8Krempler A,Henry MD,Triplett AA,et al.Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1 /S and p53-independent cell death[].Journal of Biological Chemistry.2002
  • 9Wagner KU,Krempler A,Qi Y,et al.TSG101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues[].Molecular and Cellular Biology.2003
  • 10Feng GH,Lih CJ,Cohen SN.TSG101 protein steady-state level is regulated posttranslationally by an evolutionarily conserved COOHterminal sequence[].Cancer Research.2000

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  • 1孙丽萍,宫月华,王兰,董明,袁媛.辽宁庄河地区居民血清胃蛋白酶原含量检测分析[J].中华消化杂志,2006,26(10):649-652. 被引量:37
  • 2廖峰,陈映霞,何泽明,秦叔逵,钱军,王广贤.糖类抗原CA72-4、CA19-9在胃癌诊断中的应用价值[J].放射免疫学杂志,2007,20(1):28-30. 被引量:15
  • 3马颖杰,王惠吉,武抗美.血清胃蛋白酶原与良、恶性溃疡[J].临床和实验医学杂志,2007,6(5):24-26. 被引量:29
  • 4周红凤,刘丹,吴瑾,王雯.胃蛋白酶原和胃癌相关抗原与胃癌的研究进展[J].世界华人消化杂志,2007,15(17):1940-1946. 被引量:30
  • 5Jung M, Jeung HC, Lee SS, et al. The clinical significance of ascitic fluid CEA in advanced gastric cancer with ascites [ J ]. J Cancer Res Clin Oncol,2010,136(4) :517-526.
  • 6Dardaei L, Shahsavani R, Ghavamzadeh A, et al. The detection of dis- seminated tumor cells in bone marrow and peripheral blood of gastric cancer patients by multimarker( CEA, CK20, TFF1 and MUC2 ) quanti- tative real-time PCR[J]. Clin Biochem,2011,44(4) :325-330.
  • 7Ohashi N, Nakanishi H, Kodera Y, et al. Intraoperative quantitative de- tection of CEA mRNA in the peritoneal lavage of gastric cancer pa- tients with transcription reverse-transcription concerted (TRC)method. A comparative study with real-time quantitative RT-PCR[ J ]. Antican- cer Res, 2007,27 (4 C ) :2769 -2777.
  • 8Takahashi Y. Gastrointestinal cancer [ J ]. Gan To Kagaku Ryoho, 2004,31 (8) :1275-1279.
  • 9Kim HJ, Lee KW, Kim Y J, et al. Chemotherapy-induced transient CEA and CA19-9 surges in patients with metastatic or recurrent gastric cancer[ J]. Acta Onco1,2009,48 ( 3 ) :385-390.
  • 10Zhang YH, Li Y, Chen C, et al. Carcinoembryonic antigen level is re- lated to tumor invasion into the serosa of the stomach:study on 166 ca- ses and suggestion for new therapy[ J]. Hepatogastroenterology,2009, 56 (96) : 1750-1754.

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