咳嗽变异性哮喘患儿血清巨噬细胞炎性蛋白-1α水平的变化及其意义

Changes of Concentration of Serum Macrophage Inflammatory Protein-1α in Children with Cough Variant Asthma and Its Significance

目的探讨咳嗽变异性哮喘患儿血清巨噬细胞炎性蛋白-1α(MIP-1α)水平的变化及其在鉴别诊断中的临床价值。方法选择我院收治的感染性咳嗽患儿(感染性咳嗽组)49例,咳嗽变异性哮喘患儿(咳嗽变异性哮喘组)37例及体检无异常儿童30例(正常组),检测并比较3组儿童的血清MIP-1α水平。结果3组儿童的血清MIP-1α水平间差异有统计学意义(P<0.01)。其中感染性咳嗽组、正常组与咳嗽变异性哮喘组比较血清MIP-1α水平间差异均有统计学意义(P<0.05);而感染性咳嗽组与正常组儿童血清MIP-1α水平间差异无统计学意义(P>0.05)。咳嗽变异性哮喘患儿血清MIP-1α水平与咳嗽的持续时间呈正相关(P<0.05)。结论血清MIP-1α水平可反映气道炎症类型,是鉴别感染性咳嗽与咳嗽变异性哮喘的一项参考指标。

Objective To evaluate the changes of Serum Macrophage Inflammatory Protein-1α （ MIP -1α） level and its application in differential diagnosis of cough variant asthma （CVA）. Methods Serum samples were obtained from 49 children with chronic persistent postinfectious cough （group Ⅰ ） , 37 with CVA （ group Ⅱ） and 30 normal （group Ⅲ ）, to determine the concentration of MIP-1α. Results There was a positive correlation between the three groups （ P 〈 0. 01 ）. Group I was significantly different from group Ⅲ in MIP -1α level （ P 〉0. 05）. There was a significantly positive correlation in the level of MIP -1α between group Ⅱ and group Ⅰ （ P 〈 0.05 ）, between group Ⅱ and group Ⅲ （ P 〈0. 05 ）. conclusion The concentration of MIP-1α, which can reflect the types of airway inflammation, is a useful marker to distinguish posfinfectious cough from CVA.