口腔颊癌对血粘性状的影响

Experimental Study on Hemorheology During DMBA Induce Golden Hamster Cheek Pouch Carcinoma

二甲基苯并蒽诱导地鼠颊囊癌过程中动态检测其血液流变性，发现肿瘤生成后的全血比粘度和血浆比粘度均明显升高，血液粘滞程度随肿瘤的生长而加重。肿瘤的形成导致了血中大分子物质的增加，使血细胞表面负电荷减少，聚集力增强，引起高粘滞血症。低切变率下，血粘度随肿瘤的发展而逐渐升高；高切变率下，肿瘤早期由于影响血液粘度改变的因素较弱，故血粘无变化，后期才明显升高。提示：肿瘤能引起高粘血症，而高粘血症又能促使肿瘤发展。

Premalignant lesions and tumor of hamster cheek pouch was imduced by 7.12-Dimethylbenzanthracene(DMBA) were studied by detecting of hemorheology. The results displaied, there was not variation of blood viscosity and others indices of hemorheology befor cheek pouch canceration and carcinoma could initiation the change of hemorheology during tumor development. Among those changes, the most dramatic change was the sharp rise of blood viscosity caused by plasma fibrinogen increasing. Cancer could not make the total number of blood cells changing. It was positive relation between the hemorheology indices changing leading to tumor and microcirculation obstruction degree. We discussed the factors which determines blood viscosity. We also preliminary posed that the mechanism of hemorheology indexes changing were leaded to cancer.