乳腺癌局部区域复发的再治疗

Retreatment of localregional recurrent breast cancer

目的：评价乳腺癌局部区域复发再治疗的效果，探讨影响复发性乳腺癌预后的主要因素。方法：１９９１～１９９３年我院治疗３４例局部区域复发性乳腺癌患者，经过３年随访，应用多因素生存分析方法，对影响生存时间的因素进行分析，并对不同治疗方法的３年生存率进行比较。结果：首次治疗时病期、复发时间、治疗方法影响生存时间（Ｐ＜０．０５）。局部放疗加化疗、内分泌治疗组的３年生存率（５８．３３％、８１．８２％）比单纯局部放疗组（１８．１８％）高（Ｐ＜０．０５）。结论：首次治疗时病期、复发时间、治疗方法是影响复发性乳腺癌预后的重要因素，治疗上应以综合治疗为主。

Objective: To evaluate the effects of retreatment of localregional recurrent breast cancer and the main factors that affect the prognosis. Methods: From 1991～1993, 34 patients with localregional recurrent breast cancer were treated in our hospital. Through 3 years' following-up, we analysize the factors that affect survival time and compare the 3-year survival rate of different treatment by using multi-factor survival analysis method. Results: Our data show that several factors affect the survival time, including the stage at the first therapy, the time between operation and relapse and the treatment (P<0.05). The survival rate of local radiotherapy combined with chemotherapy, hormonetherapy group (58.33%, 81.82%) is higher than that of only local radiotherapy group (18.18%)(P<0.05). Conclusion: The stage at the first therapy, the time between operation and relapse and the treatment are the important factors that affect the prognosis of relapsed breast cancer. The combined therapy is chief in the treatment of recurrent breast cancer.