三唑仑和扎莱普隆对晨起认知功能影响的对照研究

Control Study on the Effects of Triazolam and Zaleplon on Morning Cognitive Function

【目的】探讨睡前服用三唑仑和扎莱普隆对晨起后认知功能的影响。【方法】采用单盲交叉设计，10位健康志愿者先在未服药状态下进行威斯康星卡片分类测验（WCST）、连续作业测验（CPT）、连线测验（TMT）、数字符号测验（DST）、复合反应时间测验（CRT），然后分别在睡前服用三唑仑0．25mg或扎莱普隆10mg（清洗期1周），睡眠8h晨起后再进行上述指标测定。【结果】各项测量指标在基础对照组、三唑仑组、扎莱普隆组之间的两两比较均无显著性差异（P〉0．05）。【结论】睡前服用0．25mg三唑仑或10mg扎莱普隆，对睡眠8h后的认知功能无影响。

[Objective]To explore the effects of triazolam and zaleplon on morning cognitive function after 8-hour sleep. [Methods]In the single-blind crossover trial, a series Of cognitive measurements including Wisconsin card sorting test （WCST）, continuous performance test （CPT）, trail making test （TMT）, digit-symbol test （DST） and complex reaction time （CRT） were used to evaluate cognitive function in 10 healthy subjects in baseline and after 8-hour sleep with administration of triazolam 0.25mg or zaleplon 10mg . The washout period between the two administrations was one week. [Results]No significant differences were found in all measurements among the baseline group, triazolam group and zaleplon group （ P 〉0.05）. [Conclusion] The administration of triazolam 0.25mg or zaleplon 10mg does not affect morning cognitive function after 8- hour sleep in healthy subjects.