基础激素水平在判断卵巢储备功能中的作用

Prognostic Value of Basal Hormone Levels on Ovarian Reserve

目的探讨不孕症患者基础激素水平在判断卵巢储备功能中的作用。方法采用放射免疫方法测定６０例１１２个促排卵周期周期第２天血卵泡刺激素（ＦＳＨ）、黄体生成素（ＬＨ）及雌二醇（Ｅ２）水平，Ｂ超观察卵泡发育情况，监测有无妊娠发生，分析基础激素水平与卵巢反应性、优势卵泡数目及周期妊娠率的关系。结果周期第２天血ＦＳＨ≥１５ＩＵ／Ｌ者，卵巢反应性差发生率高，优势卵泡数目少，周期妊娠率低。周期第２天血Ｅ２≥４５ｎｇ／Ｌ者，周期妊娠率低于血Ｅ２＜４５ｎｇ／Ｌ者。周期第２天血ＬＨ值与周期妊娠率无关。结论周期第２天血ＦＳＨ可作为判断卵巢储备功能的指标，而周期第２天血Ｅ２值对血ＦＳＨ值判断卵巢储备功能有辅助作用。

Objective To study the prognostic value of basal hormone levels on ovarian reserve during ovulation induction Methods Day 2 serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E 2) levels of 112 ovulation induction cycles (60 infertile patients) were measured by radioimmunoassay. The relationship between basal hormone levels and numbers of dominant follicles and pregnancy rates were analysed. Results Day 2 serum FSH≥15 IU/L predicted a poor response to ovarian stimulation, with fewer dominant follicles and lower pregnancy rate, so was day 2 serum E 2≥45 ng/L. Day 2 serum LH level was unrelated to pregnancy rate. Conclusion Day 2 FSH and E 2 levels are useful in prognostic assessment of ovarian reserve.