P53蛋白表达在结直肠腺癌患者预后中的意义

Prognostic Significance of P53 Protein Expression in Patients with Colorectal Adenocarcinoma

为了研究Ｐ５３蛋白异常表达在结直肠腺癌患者预后中的意义，应用Ｐ５３单克隆抗体、ＡＢＣ免疫组化方法结合微波炉抗原修复法研究４０例结直肠腺癌的Ｐ５３蛋白异常表达与预后的关系。结果显示：６５％（２６／４０）的结直肠腺癌为Ｐ５３蛋白异常表达阳性。阳性病例的五年存活率为５０％（１３／２６），而阴性病例为８５７％（１２／１４），提示Ｐ５３蛋白异常表达与结直肠腺癌预后关系密切（Ｐ＜００５），可能成为一个新的预后判测指标。如结合传统的预后判测因素。

In order to investigate the prognostic significance of P53 protein expression in the patients with colorectal adenocarcinoma,we used the P53 monoclonal antibody and ABC immunohistochemical method combined with the repairing method for antigen by microwave oven to study the relationship between the overexpression of P53 protein and the prognosis in 40 cases of colorectal adenocarcinoma.The results showed that 65% (26/40) cases of colorectal adenocarcinoma were positive for overexpression of P53 protien.The 5 year survival rate for positive cases was 50%,but 87.5% for negative cases.These findings suggest that the overexpression of P53 protein closely associates with the prognosis in colorectal adenocarcinoma ( P <0 05),thus it might become a new prognostic indicator.The prognosis in colorectal adenocarcinoma could be predicted thoroughly by considering the expression of P53 protein in combination with the traditional prognostic factors.