相控阵热疗法配合灌注化疗治疗恶性胸腹腔积液

Phased array hyperthermia treatment combined with perfusion chemotherapy to cure malignant pleural & peritoneal effusion

目的观察相控阵热疗法配合灌注化疗治疗恶性胸腔或腹腔(下称胸腹腔)积液的近期疗效。方法两组均采用胸腹腔闭式引流,尽量引净积液,给予胸腹腔内注药:白细胞介素-2(IL-2)200万～300万单位,顺铂40～60mg,(丝裂霉素,五氟尿嘧碇),每周1次,共注射2～3次。联合组每次注药后2h内给予相控阵热疗50～60min,温度41～43.5℃,每周1～2次,共8～10次;对照组单给予灌注化疗观察近期疗效及不良反应。结果联合组有效率92%,对照组有效率60%,两组相比具有统计学意义(P<0.05)。结论热疗配合灌注化疗治疗恶性胸腹腔积液,能有效控制胸(腹)水,无明显不良反应,能明显改善患者生活质量。

Objective To observe the short term therapeutic effect of phased array hyperthermia treatment combined with perfusion chemotherapy to cure malignant pleural ＆ peritoneal effusion. Methods All patients under went closed thoracic or celiac drainage to drain the effusion as much as possible, and received intracelial medication （IL-2 2 000 000-3000 000 IU; eisplatin 40-60 mg; mitomyein ＆ 5-FU,once a week,2 or 3 times in total）. The combined group received phased array hyperthermia treatment for 50-60 minutes within 2 hours after perfusion of medicine, temperature 41℃-43.5℃, 1 or 2 times per week,8-10 times in total; the control group merely received perfusion chemotherapy. The short term curative effect and adverse reaction were observed. Results The effective rate of the combined group and the control group was 92% and 60% respectively. There was statistical difference （P〈0.05）. Conclusion Phased array hyperthermia treatment combined with perfusion chemotherapy is effective to cure malignant pleural ＆ peritoneal effusion,and it can effectively control effusion,improve the life quality of patients,and has no adverse reaction.