小儿哮喘过敏原的特异性IgE抗体的实验研究

The Experimental Study on the Specific IgE(SIgE)Antibody in Ashman Children

采用ＣＡＴ—ＲＡＳＴ法对１６１例哮喘患儿的吸入性抗原及食物性抗原的特异性ＩｇＥ（ＳＩｇＥ）进行检测，结果如下：①各年龄组随年龄的增长，对吸入性抗原产生的ＳＩｇＥ阳性种类增多。②随着年龄的增长，吸入性抗原ＩｇＥ阳性率增高，而食物性抗原ＩｇＥ阳性率减少。③小儿哮喘随着年龄增长，过敏原的ＩｇＥ抗体阳性率从食物性向吸入性移行，为小儿变态反应进行曲（ｍａｔｃｈ）学说提供了病因学研究。④１６１例患儿中总ＩｇＥ阳性者１０４例，其中ＳＩｇＥ全部阳性，而总ＩｇＥ阴性者５７例中ＳＩｇＥ阳性者２６例。

The specific IgE antibodies of absorbtive antigens and food antigens in 161 ashman children were measured with CAP RAST.The result showed that:(1)with the age increas,the positive number of SIgE antibodies produced by absorbtive antigens was also increased,but that by food antigens was decreased.(2).with theage increase,positive rate of absorbtive antigens IgE increase,but positive rate of food antigens IgE decrease.(3).with the age icrease,the allergic antigens shift from food to absorbtive,which supplied etiologic research for allergic match.(4)the IgE positive number was 104 in 161 cases.All of their SIgE were positive. 57 cases were total IgE negative,26 cases were SIgE positive in 57 cases of total IgE negative.This result revealed that measurement of SIgE antibodies is more sensitive.