抑郁症患者血清一氧化氮及一氧化氮合成酶的检测及其临床研究

Measurement of nitric oxide levels and activity of nitric oxide synthetase in the patients with depression

目的探讨血清NO、一氧化氮合成酶（NOS）活力与抑郁症的关系。方法纳入136例符合中国精神障碍分类与诊断标准的抑郁症患者（实验组）和120名健康志愿者（对照组），进行血清NO水平及NOS活力的检测，并进行对照分析。结果实验组血清NO水平（70．05±10．34）μmol／L及NOS活力平均水平（29．49±5．12）U／L均高于正常对照组[（67．17±16．52）μmol／L、（26．99±2．87）U／L]，差异均有统计学意义（P均〈0．05）；抑郁症患者中服药组血清NO水平（74．42±8．80）μmol／L及NOS活力平均水平（27．71±5．46）U／L均低于未服药组[（78．81±12．28）μmoL／L、（30．49±4．65）U／L]，两者相比，差异有统计学意义（P均〈0．05）。结论抑郁症患者血清NO水平及NOS活力升高，NO升高可能是抑郁症发病的影响因素；抗抑郁药可能通过降低血清NO水平而起到抗抑郁作用。

Objective To measure the correlation between the levels of blood serum nitric oxide（NO） ,the activity of nitric oxide synthetase（NOS） and depression. Methods 136 patients with depression were diagnosed by CCMD-3 and 120 healthy control subjects were included in the study. NO and NOS levels in blood serum of both groups were tested, and the variation of NO and NOS between the two groups were compared. Results The blood serum NO levels[ （70.05 ±10.34） μmol/L vs. （67.17 ±16.52） μmol/L] and the activity of NOS [ （29.49 ±5.12） U/L vs. （ 26.99 ±2.87 ） U/L ] in the patients with depression were significantly higher than those in the control group（ P 〈 0.05 ）. The blood serum NO levels and the activity NOS in the treatment patients was lower than the otherpatients[（74.42 ±8.80）μmol/Lvs.（78.81±12.28） μmol/L;（ 27. 71±5. 46 ） U/L vs. （ 30.49±4.65 ） U/L,P 〈 0.05 ]. Conclusion The blood serum NO levels and the activity of NOS increase in the patients with depression. NO might be involved in the pathogenesis of depression. The antidepressants might descend the NO levels so to relieving depression.