猪繁殖与呼吸综合征免疫学研究进展

Progress in Immunology of Porcine Reproductive and Respiratory Syndrome(PRRS)

综述了近年来PRRSV感染后免疫学方面的最新研究进展。猪繁殖与呼吸综合征病毒(PRRSV)感染后,机体能产生快速强烈的体液免疫反应,但早期产生的抗体不仅不能产生免疫保护,反而会通过介导抗体依赖增强作用产生危害,而具有中和作用的抗体产生缓慢。在PRRSV的免疫应答中,体液免疫和细胞免疫反应都很特别。

The article reviews the cell - mediated immunity, humoral immunity, immunity regulation, virulence variation and vaeeine research on poreine reproductive and respiratory syndrome virus （PRRSV）. PRRSV - infected pigs develop a strong and rapid humoral response, while these initial antibodies do not confer protection and can even be harmful by mediating an antibody -dependent enhancement of disease. In contrast, the development of neutralising antibodies （NAs） is delayed. The generation of cell- mediated immune responses, such as PRRSV - specific interferon （IFN） - γsecreting cells, is initially erratic. In spite of this, the induction of strong and rapid NAs and IFN -γresponses seem to be required for effective vaccination.