通心贴抑制冠心病肾阳亏虚兼痰瘀内阻证患者冠状动脉炎症反应的临床研究

Effect of Tongxintie on Inflammatory Response of Coronary Artery Disease in Syndrome of Kidney-Yang Deficiency complicated with Stagnation of Phlegm and Blood Stasis

目的观察通心贴对冠心病(CHD)肾阳亏虚兼痰瘀内阻证患者冠状动脉炎症反应的抑制作用。方法将80例CHD肾阳亏虚兼痰瘀内阻证患者随机分为两组,治疗组41例,膻中穴、心俞穴二穴交替贴敷通心贴,每穴贴敷每次12h,每日1次,治疗3周;对照组39例,口服麝香保心丸,每次2粒(每粒22.5mg),每日3次,治疗3周。分别于治疗前后采集空腹肘静脉血,测定血清高敏性C-反应蛋白(hs-CRP)、白细胞介素-18(IL-18)、巨噬细胞集落刺激因子(M-CSF)水平。结果两组治疗后血清hs-CRP、IL-18、M-CSF水平均明显降低(P<0.01),但治疗组hs-CRP降低程度优于对照组(P<0.05)。结论通心贴具有抑制冠状动脉炎症反应作用,这可能是其治疗冠心病肾阳亏虚兼痰瘀内阻证的机制之一。

Objective To study the effects of Tongxintie on inflammatory response of coronary artery in CHD patients （pts） with syndrome of Kidney - Yang deficiency complicated with stagnation of phlegm and blood stasis. Methods Eighty CHD pts with syndrome of Kidney - Yang deficiency complicated with stagnation of phlegm and blood stasis were randomly divided into two groups： Treatment group （n=41） and control group（n=39）. Tongxintie was used on acupoint Tanzhong （CV17） and Xinshu （BL15） in treatment group for 3 weeks. The Shexiangbaoxin Pills were given in control group for 3 weeks. The serum levels of serum high sensi tivity c - reactive protein （hs CRP）, interleukin - 18 （IL- 18） and macrophage - colony stimulating factor （M -CSF） were detected. Results Following treatment for 3 weeks,the serum levels of hs CRP,IL- 18, M - CSF in both groups were all decreased significantly （P〈0.01）. The level of serum hs - CRP in treatment group was lower than that in control group （P〈0.05）. Conclusion Tongxintie had effects on inflammatory response of coronary artery, which might be one of the mechanisms of Tongxintie for treatment of CHD with syndrome of Kidney - Yang deficiency complicated with stagnation of phlegm and blood stasis.