芪苈强心胶囊对慢性心衰神经内分泌异常激活的调节研究

Regulation of qiliqiangxin capsule on abnormal activation of nerve and endocrine in patient with chronic heart failure

目的探索调节慢性心衰神经内分泌异常激活更有效的疗法。方法采用前瞻随机设计比较三种治疗方法对93例慢性心衰病人神经内分泌异常激活的调节情况。结果洛丁新、倍他乐克、安体舒通联合可以降低慢性心衰病人血浆肾素、血管紧张素Ⅱ、醛固酮,与对照组比较有统计学差异,加用芪苈强心胶囊可以进一步改善心功能,提高生活质量,但未进一步下调血浆肾素、血管紧张素Ⅱ、醛固酮水平。结论洛丁新、倍他乐克、安体舒通下调慢心衰神经内分泌的异常激活,加用芪苈强心胶囊未能使调节更有效,但可以改善心功能,提高生活质量。

Objective To find the effective technique of regulating abnormal activation of nerve and endocrine in the patient with chronic heart failurc（CHF）. Methods Ninety-three patients with CHF were randomly prospectively divided into three groups and treated with Lotensin, Betaloe, Spironolactone （group A）, and Qiliqiangxin eapsule（groupB） and basic treatment group respectively and observed which was better. Results Group A was went down the level of renin, angiotensin Ⅱ , aldosterone on patients with CHF. Group B is not more went down the levels, but it can improve heart function. Conclusion Lotensin,Betaloc,Spironolactone are effective on regulating abnormal activation of nerve and endocrine in the patient with CHF. Qiliqiangxin capsule is not better than Lotensin, Betaloc, Spironolactone on regulate abnormal activation of nerve and endocrine in the patient with CHF,but it can improve the quality of life and heart function.