埃索美拉唑三联与奥美拉唑三联治疗HP阳性十二指肠溃疡的临床对比研究

Comparison of esomeprazole and omeprazole based triple therapy regimens for duodenal ulcer with helicobacter pylori infection

目的比较埃索美拉唑三联与奥美拉唑三联治疗HP阳性十二指肠溃疡的临床疗效。方法将82例HP阳性的十二指肠溃疡患者随机分为2组。EAC组(埃索美拉唑+阿莫西林+克拉霉素)和OAC组(奥美拉唑+阿莫西林+克拉霉素);EAC组41例,OAC组41例,疗程2周。4周后复查胃镜并检测HP,观察溃疡愈合率、HP根除率及临床症状缓解情况等。结果EAC组前三天临床症状缓解率分别为34.1%、58.5%和70.7%,明显高于OAC组14.6%、36.6%和58.5%(P<0.05);EAC和OAC组溃疡愈合率为95.1%和92.7%,HP根除率为87.8%和85.3%(P>0.05)。两组用药后安全性好,不良反应少。结论埃索美拉唑三联治疗HP阳性的十二指肠溃疡临床症状缓解速度优于奥美拉唑三联治疗。

Objective To investigate the efect of esomeprazole-and omeprazole hased triple therapy regimens in the treatment of duodenal ulcer with Hdicobacter pylofi （HP）infection. Methods 82 patients with duodenal ulcer and HP infection were randomly divided into two groups. EAC group （41 cases）treated with esomeprazole amoxieillin and clarithromyein twice daily and OAC group （41 cases） treated with omeprazole,amoxicillin and darithromycin twice daily. The treatment lasted for 14 days, at＇ter which ulcer healing rate and eradication rate of HP as well as clinical remission rate were evaluated and compared. Results On the first, the seoond and third days of medication, the clinical remission rates were 34.1%, 58.5 % and 70.7 % respectively in group EAC, significantly higher than those in group OAC（ 14.6 %, 36.6 % and 58.5 %, respectively, P 〈 0.05）, ulcer healing rate and HP eradication rate were 95.1% and 92.7 % in group EAC and 87.8 % and 85.3 % in group OAC, showing no significant diferences between the two groups（P 〉0.05）. The adverse effects of the medication were rare in both groups without significant differences. Conclusion Esomeprazole Based triple therapy may capable of achieving more speedy clinical remission than omepramle based therapy.