^(131)I-MG_7胃癌内注射治疗的临床研究

CLINICAL STUDY OF RADIOIMMUNOTHERAPY(RIT)ON GASTRIC CARCINOMA BY ENDOSCOPIC INTRATUMOR INJECTION WITH ^(131)I-MG_7

应用１３１Ｉ－ＭＧ７对９例胃癌病人行内镜下癌内多点注射法放射免疫治疗（ＲＩＴ），另两例仅以１３１Ｉ－ＮａＩ胃癌内注射作为对照。注射后应用ＳＰＥＣＴ对放射免疫显像（ＲＩ）行系列观察。ＲＩ满意组５例中胃癌区均见放射性浓聚，以癌性溃疡区最浓，Ｔ／ＮＴ比值高，平均２．３６～１１．１６，维持８～１７天以上。治疗后１～２月癌组织活检病理复查有明显的放射效应，已达到了ＲＩＴ内放射治疗的要求和目的，说明内镜下胃癌内注射１３１Ｉ－ＭＧ７ＲＩＴ具有临床应用前景。

9 patients with gastric carcinoma subjected to endoscopic intratumor injection of 131IMG_7 and 2 of 131INaI as control to assess clinical feasibility of this method of RIT.The radioimmunoimages(RII)scanned every 24～48 hours with SPECT.The injected sites were visualized distinctly in 8 cases of RIT group and 2 controls,but marked radioactive aggregations in tumor viewed in 5 of RIT group with high T/NT ratio for about 8～17 days.The pathological responses following local radiation were evident while clinical symptoms improved transiently,no side effect being observed.RIT with endoscopic intratumor injection of 131IMG7 is clinically feasible and safe,it would be a method of choice for advanced gastric carcinoma if appropriate doses of 131 I and MG7 are managed.