不同部位胃腺癌和幽门螺杆菌感染

GASTRIC ADENOCARCINOMA AND HELICOBACTER PYLORI INFECTION

为研究幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，Ｈｐ）与胃腺癌的关系，对８５例（３５例位于贲门部和５０例位于非贲门部）组织学证实的胃腺癌患者和８５例对照者进行Ｈｐ检测。胃镜检查时，取胃粘膜活检标本，用快速型尿素酶试纸和血清抗Ｈｐ抗体法检验来确定Ｈｐ感染。结果显示：（１）胃腺癌患者Ｈｐ阳性率（７０．６％）高于对照组（４１．４％），Ｐ＜０．０１；（２）不同部位胃腺癌Ｈｐ阳性率分别为胃窦８７．５％，胃体７０．０％，胃底８１．３％均高于贲门部癌（５４．２％），差异有显著性（Ｐ＜０．０１）。

To determine the association of Helicobacter pylori infection with gastric cancer,the presence of Hp infection in 85 patients with histologically confirmed gastric adenocarcinoma(35 with cancer at cardia and 50 at other sites)was assayed by rapid urease test using specimens collected at endoscopic examination and by serum antibody of Hp.The results showed:1.The detection rate of Hp was higher in patients with gastric adenocarcinoma than in controls,706%vs 414%(P<001);2.All patients with gastric adenocarcinoma located at other sites(gastric antrum,875%;gastric body,700%;fundus,813%)had a higher prevalence of Hp than those located at cardia(542%),the difference was significant(P<001)This seems to support the hypothesis that an association is existed between Hp infection and development of gastric carcinoma,especially in the case of noncardiac gastric adenocarcinoma.