胃癌微卫星不稳定性研究

STUDY OF MICROSATELLITE INSTABILITY IN GASTRIC CANCER

为了研究微卫星不稳定性（ＭＳＩ）在胃癌发生中的作用，使用ＰＣＲ为基础的方法检测５０例胃癌活检标本的ＭＳＩ。结果发现：胃癌ＭＳＩ阳性率为３４％（１７／５０），其中两个位点ＭＳＩ均阳性者占ＭＳＩ阳性病例的５８．８％（１０／１７），３例早期胃癌ＭＳＩ均阳性，进展期胃癌ＭＳＩ阳性率为２９．８％（１４／４７）。中—高分化腺癌ＭＳＩ阳性率（６０％）显著高于低分化腺癌（１９．４％）（Ｐ＜０．０５）。ＭＳＩ与胃癌部位、大小、Ｌａｕｒｅｎｓ分型、淋巴结转移、浆膜浸润及分期无明显相关。以上结果提示，ＭＳＩ在胃癌的发生中可能起重要作用，是胃癌的一种早期分子标志。检测ＭＳＩ可能成为胃癌高危人群的筛选。

The purpose of this study was to evaluate the role of microsatellite instability(MSI) in the development of gastric cancer (GC).Using PCRbased method,MSI was investigated in 50 bioptic specimens of GC obtained endoscopically.The total incidence of MSI in GC was 340%(17/50).The frequency of MSI in the mildhigh differentiated group(60%)was significantly higher than that in poorly differentiated group(194%)(P<005).No significant correlation was found between MSI and tumor location ,size,lymphnode metastasis,serosal invasion and clinical stage.The results suggested that MSI,an early molecular marker in the development of GC play an important role in carcinogenesis of GC,and that determination of MSI be useful in screening high risk population and in early diagnosis of GC.