H-ras、N-myc及nm^(23)-H_1癌基因蛋白在基底细胞癌中的表达

Expression of H-ras、N-myc and nm^(23)-H_1 oncoproteins in basal cell carcinoma

应用免疫组化技术研究18例基底细胞癌、4例鳞状细胞癌、3例角化棘皮瘤及4例正常皮肤组织中H-ras、N-myc及nm23-H1癌基因蛋白的表达。结果表明：H-ras蛋白产物主要分布于分化较成熟的组织，而N-myc则分布于持续生长的组织及较成熟组织，nm23-H1蛋白产物在基底细胞癌中表达最强，而在鳞状细胞癌中表达最低。结果提示：H-ras和N-myc基因在基底细胞癌和鳞状细胞癌的发生发展中具有协同作用；nm23-H1基因则对抑制基底细胞癌的转移起了一定作用。

The expression of H-ras. N-myc and nm23-H1 oncoproteins were investigated by immunohistochemical technique using monoclonal antibodies to H-ras. N-myc anc nm23-H, oncoproteins in 18 patients with hasal cell carcinoma (BCC). 4 patients with squamous cell carcinoma (SCC) 4 patients with keratoacanthoma (KA) and 4 patients with normal persons. The results showed that H-ras oncoprotein distributed inwell-differentiated tissue. while N-mys oncoprotein disthbuted in persistent growing and fairly well-differentiated tissue and nm23-H1 oncoprotein was expressed stronger in BCCthan in SCC. We conclude that H-ras and N-myc oncogenes may be synergic on the occurrence and development of BCC and SCC. and nm23-H1 gene may play a role in the suppression of metastasis of BCC.