斑秃患者血清TNFα水平观察

Observation of serum TNFα level in alopecia areata patients

测定70例斑秃患者血清肿瘤坏死因子-α（TNFα）水平。测定结果示斑秃患者TNFα明显高于对照组（P＜0．01）。活动期患者明显高于静止期（P＜0.01）。而单纯斑秃组与全、普秃组相比，则无明显差异（P＞0．05）。表明斑秃患者存在着免疫功能异常，并与斑秃的发病及病情活动有关。

Serum TNFα levels were detected in 70 cases of alopecia areata (AA). The results showed that TNF-a level of the patients was obviously higher than that of controls (P < 0. 01 ), and the level was significantly higher in active stage than that in stead}stage (P < 0. 01 ), There were no obvious differences (P > 0. 05) in the levels of TNFα among AA, alopecia totalis and alopecia universalis groups. It suggests that the immunologic function of AA patients is abnormal, which may play a role in the pathogenesis of alopecia areata and disease activity.