微量元素与太行山区三县西部山区胃癌发病的相关性研究

Relationship between Trace Elements and the incidence of gastric cancer of the Taihang Mountains area

目的探讨邢台县、沙河县、临城县三县西部山区村庄胃癌患者体内部分微量元素与胃癌发病的关系。方法采用美国Perkin-Elemer 603 AAS原子吸收分光光度计对60例胃癌患者血清及肿瘤组织中铜、铁、锌、硒、镉5种微量元素的含量进行测定,并以60名健康人血清为对照。结果与对照组相比,胃癌患者血清中铜、镉含量和铜、锌比值明显增高,而锌、硒、铁含量降低,差异有统计学意义(P<0.05);胃癌患者癌组织中铜、镉含量和铜/锌比值明显高于血清,而锌、硒含量则明显低于血清(P<0.05),两者之间差异无统计学意义(P>0.05)。结论微量元素及其比值的改变与太行山区三县农村胃癌的发生存在着密切的关系。

Objecti To investigate the relationship between the trace elements in vivo and the incidence of stomach cancer in the west mountainous area village of XingTai county, ShaHe county and LinCheng county. Methods With Perkin-Elemer 603, the atomic absorption spectrophotometer, we measured the trace element content of 60 serum samples in the stomach cancer patients and the copper, the iron, the zinc, the selenium and the cadmium of the tumor tissues, and took 60 healthy persons as the normal control. Results The result showed that compared with the control group, in stomach cancer patients, blood serum copper, cadmium content and copper/zinc ratio were obviously increased, hut the zinc, the selenium, the iron content were reduced, the difference has the significance （P 〈 0.05）; The copper, the cadmium content and copper/zinc ratio of stomach cancer tissues are higher than those in the normal blood serum obviously, but the zinc, the selenium content are obviously lower （P 〈 0.05）, both difference were not significant （P〉0.05）. Conclusion The trace elements and their ratio change have the close relationship with stomach cancer＇s occurrence in three counties of Mr. Taihang area.