胰蛋白酶抑制剂对实验性缺血性脑水肿的作用

Effects of trypsin inhibitors on experimental ischemic brain edema

目的观察各种胰蛋白酶抑制剂对大鼠缺血性脑水肿的作用。方法大鼠脑缺血模型采用线栓法，脑含水量测定采用称重法，常规病理学检查。结果５５ｍｇ／ｋｇ和１６５ｍｇ／ｋｇ胰蛋白酶抑制剂（ＳＢＴＩ）对ＬＭＣＡＯ３ｈ大鼠脑含水量无显著影响（Ｐ均＞０．０５）；６６０００ＫＩＵ／ｋｇ特血乐、５００００Ｕ／ｋｇ尿胰蛋白酶抑制剂（ＵＴＩ）可显著降低脑水肿大鼠脑含水量（Ｐ均＜０．０５），并可减轻缺血区神经元变性及间质水肿程度。结论６６０００ＫＩＵ／ｋｇ特血乐、５００００Ｕ／ｋｇＵＴＩ具有减轻实验性缺血性脑水肿的作用。

Objective To study effects of trypsin inhibitors on ischemic brain edema of rat.Methods Brain water content was calculated by dryingweighting method and histopathologic changes were observed by light microscope.Results There was no significant change in brain water content in the groups treated with 55mg/kg SBTI and 165mg/kg SBIT(all P>0.05).In the groups which treated with 66 000KIU/kg trasylol or 50 000U/kg ulinastatin,water content of ischemic rat brain reduced significantly(all P<0.05) and histopathologic changes within ischemia area also attenuated.Conclusion Experimental ischemic brain edema could be reduced by 66 000KIU/kg trasylol and 50 000U/kg ulinastatin.