老年高血压患者阿托伐他汀治疗后血清CRP及内皮舒张功能变化及其临床意义

Effects of atorvastatin on serum CRP and endothelium-dependent vasodilation(EDV) for senile patients with essential hypertension and its clinical significance

目的:探讨阿托伐他汀在高血压患者中的抗炎作用。方法:将78例老年高血压患者随机分为对照组和阿托伐他汀组(治疗组)。两组均常规治疗,在此基础上治疗组每晚睡前服用阿托伐他汀10 mg,共8周。检测两组治疗前后血清C反应蛋白(CRP)、血压、血脂和血管内皮依赖性舒张功能变化。结果:两组降压效果差异无统计学意义;对照组治疗后血脂、血清CRP和内皮依赖性舒张功能无明显变化,而治疗组血脂、血清CRP明显降低,血管内皮依赖性舒张功能明显改善(P<0.01)。结论:阿托伐他汀除具有降脂作用外,还具有减轻血管炎性反应、改善内皮功能的作用。

Objective To study the anti - inflammatory effects of atorvastatin in senile patients with essential hypertension. Method Total 78 senile patients with essential hypertension were randomly divided into two groups as the treatment group （n =40） and tbe control group （n = 38 ）. Each group received regular anti - hypertension treatment, the treatment group were administered orally atrovastatin （10mg/d） for 8 weeks. Blood pressure, serum TC ,TG, HDL- C, LDL- C, CRP and endotbelium -dependent vasodilation were examined in all patients before and after treatment. Results Baseline characteristics of patients between the treatment group and the control group were similar （ P 〉 0.05 ）. After 8 weeks＇treatment, there was no significant difference of blood pressure level between the two groups. Compared with the control group, the level of serum TC ,TG, HDL - C, LDL - C, CRP were significantly decreased in the treatment group （P 〈 0.05）, and there was significant improvement of endothelium - dependent vasodilation in the treatment group compared to that in the control group （ P 〈 0.05 ）. Conclusion In addition to decease blood lipid, atorvastatin can alleviate vascular inflammation response and impruvc endothelium -dependent vasedilation in senile patients with essential hypertension.