胃息肉组织中端粒酶活性的检测及其临床意义

Expression and clinical significance of telomerase in stomach polyps tissue

目的:探讨端粒酶在胃息肉中的检测及临床意义。方法:标本均系电子内镜下取得的胃息肉组织5块,3块送活检,另2块进行端粒酶活性检测。结果:增生性息肉、腺瘤、炎性息肉、幼年性息肉和息肉样胃癌组织的端粒酶阳性率分别为6.6%、18%、13.5%、0%和88%。结论:端粒酶活性检测可作为胃息肉恶变的早期预测指标。

Objective To investigate the expression and clinical significance of telomerase in human stomach polyps tissue. Method Five tissue samples in human stomach polyps were obtained through endoscope, 3 of which underwent biopsy, the other two tissue samples undertook telomerase activity assay by TRAP. Results The telomerase positive ratios were respectively 6.6% , 18%, 13.5%, 0 and 88% in proliferous polyps, denomatous polyps, inflammatory polyps, inflammatory granulomatosis and polypus intestinal carcinoma. Conclusion Expression of telomerase may be used as an early marker to predict the malighant transformation of stomach polyps.