前列腺增生组织中白细胞介素-6受体基因表达水平的检测及其意义

Expression of the interleukin-6 receptor mRNA in benign prostate hyperplasia

应用逆转录聚合酶链反应方法定量检测了10例正常人前列腺、20例前列腺增生（BPH）组织及前列腺癌细胞系PC－3m中80ku白细胞介素－6受体（IL－6R）基因表达水平。结果发现正常前列腺组织中IL－6RmRNA呈低水平表达，而43PH组织中表达增强，明显高于正常组（P＜0．01），表明BPH发生与IL－6及其受体有关。此外，还发现55．0％（11／20）BPH组织中IL－6RmRNA含量高于前列腺癌细胞系PC－3m，提示IL－6所介导的融合毒素可能成为治疗BPH新的有效途径。

With RT-PCR technique, interleukin-6 receptor (IL-6R) mRNA expression was quantitively assayed in 10 normal prostate, 20 benign prostate hyperplasia (BPH) tissues and a PCa cell line PC-3m. The results revealed that IL-6R was positively expressed in all the samples,and the expression level of BPH tissues was significantly higher than that of the normal samples (P <0. 01). In addition, 11 of 20 (55. 0% ) BPH tissues expressed higher levels of IL-6R mRNA than PC-3m. Therefore, it was suggested that IL-6 may play a role in the growth of BPH, and I1-6Rcould be a target for the delivery of therapeutic agents in BPH.