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低硒对大鼠心肌肌浆网Ca转运的影响

EFFECT OF SELENIUM DEFICIENCY ON Ca TRANSPORT OF MYOCARDIAL SARCOPLASMIC RETICULUM FROM RAT
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摘要 用克山病病区低硒粮饲料和该饲料补硒喂养大鼠,动态观察了喂养1、2和3个月时两组大鼠心肌肌浆网钙转运功能的改变。结果表明:在各喂养期,低硒组大鼠心肌肌浆网Ca2+-ATPase活性和Ca2+摄取速率均明显低于补硒组,而脂质过氧化物浓度则显著高于同期补硒组。提示低硒大鼠心肌肌浆网Ca2+-ATPase活性和Ca2+摄取下降可能是脂质过氧化增高的结果。 Two groups of weanling SpragueDawley rats were fed on a low-selenium basal diet and the same diet supplemented with sodium selenite,respectively,for 1, 2 and 3 months. At each feeding time,the Ca2+ -ATPase activity,Ca2+ uptake rateand the capacity of Ca2+ uptake in isolated cardiacsarcoplasmic reticulum from the Se-deficient ratswere decreased significantly compared to those fromthe Se-supplemented rats; but the content of lipidperoxide in sarcoplasmic reticulum from the Se-deficient rats was significantly higher than that from Sesupplemented rats. The results suggest that the enhancement of lipid peroxidation via Se deficiencymight be responsible for the decreases of Ca2+ -AT-Pase and Ca2+ uptake activities in sarcoplasmic reticulum in Se-deficient animals.
出处 《西安医科大学学报》 CSCD 1998年第2期151-154,共4页 Journal of Xi'an Medical University(Chinese)
基金 国家"七五"攻关资助!75-62-03-03
关键词 心肌肌浆网 大鼠 脂质过氧化 selenium Ca^(2+)-ATPase Ca^(2+) uptake cardiac sarcoplasmic reticulum,rat
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参考文献7

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二级参考文献7

  • 1杨志伟,聂玉生,杨福愉.超氧阴离子对心肌细胞Ca^(2+)平衡的影响及硒的保护作用[J].生物化学杂志,1994,10(2):196-201. 被引量:5
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