葛根素注射液治疗新生儿缺氧缺血性脑病25例临床观察

Clinical study of Kakonein on Hypoxicischemic encephalopathy（HIE）

目的：观察葛根素注射液对新生儿缺氧缺血性脑病（HIE）的治疗作用。方法：将45例新生儿缺氧缺血性脑病患儿随机分为治疗组（基本治疗＋葛根素）25例,对照组（基本治疗）20例,对两组患儿治疗前后一氧化氮、丙二醛、神经元特异性烯醇化酶、新生儿神经行为量表评分变化进行比较分析。结果：血浆一氧化氮、丙二醛治疗前治疗组与对照组无明显差异,治疗组治疗后较治疗前明显下降,与对照组比较差异显著（P〈0.05）;治疗组与对照组治疗前神经元特异性烯醇化酶无显著差异（P〉0.05）,治疗组治疗后较治疗前显著降低（P〈0.01）,对照组治疗前与治疗后无显著差异（P〉0.05）;治疗组与对照组治疗前新生儿神经行为量表评分无明显差异,治疗后治疗组较对照组评分差异有显著性（P〈0.05）。结论：葛根素对HIE有显著的治疗作用,值得临床推广应用。

Objective：To investigate the effects of Kakonein on Hypoxicischemic encephalopathy（HIE）. Methods ：45 patients were randomly divided into research group （n = 25, basicc treatment combined with TMP） and control group （n = 20, single basic treat- ment ） ; Before and after treatment, comparative analyses of nitricoxide （ NO ） , malondialdehyde （ MDA ） , Neuron - specific enolase ducted among the 2 groups. Results ： There were no obvious differences in plasma NO and MDA between the research group and control group, the NO and MDA of post - treatment were significantly lower than those of pretreatment and before treatment there had significant difference from the control group （ P 〈 0.05 ） ; before treatment, the NSE of the research and control groups had no significant difference （P 〉 0.05 ） and both were higher than the healthy group（ P 〈 0.01 ） , that of the research was significantly lower after treatment than before treatment（ P 〈 0.01 ） and that of the control had no obvious difference（ P 〉 0.05 ） ; the scores of the NNBAS had ,no obvious difference before treatment and did significant difference after treatment （ P 〈 0.05 ） and control groups. Conclusions： Kakonein is a brain protective agent ,which is very safe and effective and can be popularized.