肾综合征出血热患者白细胞介素-6的动态变化及意义

DYNAMIC CHANGES AND SIGNIFICANCE OF IL-6 IN PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

用双抗体夹心ELISA法检测36例肾综合征出血热102份系列血清中IL－6含量，发现患者血清IL－6含量在6病日前及发热低血压期均高于正常；6病日达高峰，7病日开始下降；发热期明显升高，少尿期达峰值；IL－6含量在轻、中、重及危重型患者之间有明显差异；IL－6与尿蛋白在含量间明显正相关。提示IL－6含量变化与病程进展一致，是引起肾病综合征出血热病理损伤的重要因素之一；且与病情轻重密切相关，可一定程度判定患者预后和转归，反映肾损伤程度。

The interleukin-6 (IL-6) concentrations in 102 serum samples sequentially collectedfrom 36 patients with hemorrhagic fever with renalsyndrome (HFRS) were determined by double antibody sandwich ELISA. It was observed that serumIL-6 concentrations in HFRS patients were elevated6 days before onset of disease and at the fever and oliguria stages of the disease in comparison with normal controls. The IL-6 concentrations in HFRSpatients reached peak value at day 6 after onset of disease and began to decrease from day 7,serum IL-6 concentrations greatly increased at fever stage,peaked at oliguria stage. There were significant differences among the IL-6 concentrations in mild.middle, severe and grave type of patients with HFRS. Serum IL-6 levels were positively associatedwith urine protein in HFRS patients. These observations suggest that the dynamic changes of IL-6 concentrations were in accord with the developments ofHFRS and that IL-6 might be one of the factorsleading to the pathologic lesions of HFRS. IL-6 was closely related to the seventy of HFRS and thus it could reflect the prognosis and outcome as well as the seventy of renal impairment of HFRS patients.