中西医结合治疗儿童过敏性紫癜的临床研究

Clinical Study on Combination of Traditional Chinese Medicine and Western Medicine in Treating Recurrent Henoch-Schonlein Purpura

目的观察中西医结合治疗儿童过敏性紫癜(Henoch-Schnlein purpura,HSP)反复发作及预防紫癜性肾炎(Henoch-Schnlein purpura nephritis,HSPN)发生的临床疗效。方法96例过敏性紫癜患儿随机分成治疗组(中西医结合治疗)和对照组,观察治疗后临床症状改善的情况,并观察治疗1个月、3个月、半年后HSP复发、HSPN发生的情况及血清免疫球蛋白IgA、血清补体C3的变化情况。结果治疗组经治疗1个月、3个月、半年后过敏性紫癜复发、紫癜性肾炎发生的情况均少于对照组(P<0.01),血清IgA、补体C3水平于治疗1个月后趋于正常,改善情况优于对照组(P<0.05)。结论中西医结合治疗可以减少过敏性紫癜复发及紫癜性肾炎的发生。

Objective To investigate the clinic effect of combined therapy of Chinese and Western Medicines in treating recurrent Henoch-Schonlein purpura（HSP） and protecting against the Henoch-Schonlein purpura nephritis （HSPN）. Methods 90 cases of children patients with allergic purpura were randomly divided into the treating group （combined therapy of Chinese and Western Medicines） and control group;observe the improvement of their clinic symptoms;and also observe the recurrence of HSP, occurrence of HSPN and the change of level of serum IgA, serum C3 for respectively after 1 month,3 months and 6 months. Results After the treatment, both the recurrence of HSP and occurrence of HSPN in treating group was less than that of the control group（ P 〈 0.01 ） ;the level of serum IgA, C3 trend to normal after 1 month＇ s treatment, and the improvement is better than that of the control group （P 〈 0.05）. Conclusion Combined therapy of Chinese and Western Medicines could decrease the occurrence of HSP and protecting against the HSPN.