卵巢上次性肿瘤ER、TNF表达及相互关系

STUDY ON TUMOR NECROSIS FACTOR (TNF) AND ESTROGEN RECEPTOR (ER) IN OVARIAN EPITHELIAL TUMOR

用肿瘤坏死因子（TNF）、雌激素受体（ER）的单克隆抗体对46例卵巢上皮肿瘤及10例正常卵巢新鲜组织的冰冻切片，进行TNF、ER免疫组化ABC法测定。结果：卵巢囊腺癌TNF及ER表达的阳性率高于卵巢囊腺瘤；临床分期越晚，TNF及ER表达强度越高。表明卵巢上皮性肿瘤TNF及ER表达与其组织学类型及临床分期有关。提示TNF在卵巢癌中的表达可预测预后，ER的表达可指导卵巢肿瘤内分泌治疗。

46 cases of fresh biopsies of the ova rian epithelial tumor and 10 cases of normal ovaries were snap frozen sectioned. Using monoclonal antibody and immunohistochemical ABC methods,we examined the expression of tumor necrosis factor (TNF) and estrogen receptor (ER) in ovarian epithelial tumor. The results showed that the positiverates of TNF and ER expression in ovarian cystadenocarcinoma were higher than those in ovarian cystadenoma. The more advanced clinical stages, the higher was the positive rate of TNF expression. butER didn't show the same change. The results indicate that TNF and ER expression is associated with tissue types of ovarian tumor and/or clinical stages.