多囊卵巢综合征患者可溶性细胞间黏附分子-1水平测定及其意义

SIGNIFICANCE AND EXPRESSION OF SERUM SOLUABLE INTERCELLUR ADHENSION MOLECULE-1 IN POLYCYSTIC OVARIAN SYNDROME

目的:通过检测多囊卵巢综合征(PCOS)患者的可溶性细胞间黏附分子-1(sICAM-1)水平,探讨其临床意义。方法:随机选取PCOS患者41例(实验组),健康人39例(对照组),测量研究对象的身高、体重和腰围、臀围,检测患者的性激素。采用酶联免疫吸附法(ELISA)对41例PCOS患者及39例健康人的血清sICAM-1水平进行检测。结果:①PCOS患者的血清sI-CAM-1水平高于正常人(P<0.05);②PCOS患者BMI≥25 kg/m2的血清sICAM-1水平比BMI<25 kg/m2水平明显升高(P<0.05);③PCOS患者中腰臀比(WHR)≥0.8的血清sICAM-1的水平比WHR<0.8的明显升高(P<0.05);④多元线性回归分析显示PCOS患者的血清sICAM-1水平与组别、年龄、BMI、WHR呈正相关。结论:sICAM-1与PCOS可能有密切的关系,随着年龄越大,WHR及BMI增大,sICAM-1水平渐增。

Objective： To investigate plasma soluble intercellular adhesion molecule-1 （sICAM-1） concentration in women with polycystic ovary syndrome （PCOS） and their clinic significance. Methods： Taking the 41 patients with PCOS as study group. The 39 healthy women were control group. Measuring height, weight, waist circumference, hip circumference, and calculating body mass index （BMI） ,waist-to-hip ratio （WHR）. The level of follicle stimulating hormone（FSH）, prolactin（PRL）, luteinizing hormone（ LH）, estrodio（E2） and testosterone （Testo）in serum in 41 patients with PCOS and in 39 healthy persons were measured by automatic chemo-immunity luminescent technique. The level of sICAM-1 in serum in 41 patients with PCOS and in 39 healthy persons were measured by enzyme-linked immunosorbent assay （ELASA）. The possible relationship between sICAM-1 and clinical materials was analyzed by multiple linear regression analysis. Result：①The sICAM-1 level in women with PCOS was higher than that of the healthy persons（P〈0.05） .②The level of sICAM-1 in serum in women with PCOS with BMI≥25 kg/m^2 was higher than that of the women with BMI〈25 kg/m^2（P〈0.05）.③The level of sICAM-1 in serum in women with PCOS with WHR≥0.8 was higher than that of the women with WHR〈0.8（P〈0.05）. ④Multiple linear regression analysis showed that the level sICAM-1 in women with PCOS was correlated positively with grope, age, BMI, and WHR, but correlated inversely with E2. Conclusion： sICAM-1 was possibly associated with PCOS. The sICAM-1 level was correlated positively with the age, WHR and BMI, which may hint that PCOS was possibly associated with cardiovascular disease. Along with age in patients in polycystic ovarian syndrome increasing gradually, cardiovascular disease chanciness was increasing especially in BMI≥25 kg/m^2,WHR≥0.8.